| THBS2 |
| LOCUS ID | 7058 | ||||||||||
| GENE_SYMBOL | THBS2 | ||||||||||
| GENE NAME | thrombospondin 2 | ||||||||||
| SYNONYMNS | TSP2 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 2438 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. This study identified that higher PIP, THBS2 and/or NGAL levels were significantly associated with nephropathy of T2DM, and higher L1CAM but normal PIP, THBS2 or NGAL was significantly associated with retinopathy of T2DM. | 27446820 |