| TIMP2 |
| LOCUS ID | 7077 | ||||||||||
| GENE_SYMBOL | TIMP2 | ||||||||||
| GENE NAME | TIMP metallopeptidas | ||||||||||
| SYNONYMNS | DDC8, CSC-21K | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 2444 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the TIMP gene family. The proteins encoded by this gene family are tural inhibitors of the matrix metalloproteises, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteises, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintence of tissue homeosta |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Losartan can prevent the development of diabetic nephropathy and inhibit MT3-MMP and the TIMP2 mRNA expressions in diabetic rat kidneys. | 15604066 |