| TIMP4 |
| LOCUS ID | 7079 | ||||||||||
| GENE_SYMBOL | TIMP4 | ||||||||||
| GENE NAME | TIMP metallopeptidas | ||||||||||
| SYNONYMNS | TIMP-4 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 37748 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. | 24458266 |