| TIRAP |
| LOCUS ID | 114609 | ||||||||||
| GENE_SYMBOL | TIRAP | ||||||||||
| GENE NAME | TIR domain containin | ||||||||||
| SYNONYMNS | Mal wyatt BACTS1 MyD88-2 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 14285 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Genetic variants in the TLR4 gene or in the IRAK1 and TIRAP genes may have an important role in the development of insulin resistance and type 2 diabetes by disrupting the inflammatory response. | 31222667 |