TKT
LOCUS ID7086
GENE_SYMBOLTKT
GENE NAMEtransketolase
SYNONYMNSTK, TKT1, HEL107
CHROMOSOME3
HOMOLOGENE ID68154
microRNAsNANA
GENE SUMMARY
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Altertively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We found combined effect of TKT SNP rs11130362 and FN3K SNP rs1056534 on DN progression (p<0.01).23492569
Neuropathy1. associations of genetic variation in transketolase enzyme with neuropathic symptoms and reduced thermal sensation in recent-onset diabetes suggest a role of pathways metabolizing glycolytic intermediates in early diabetic neuropathy.27103086