| TKT |
| LOCUS ID | 7086 | |||||||||||||
| GENE_SYMBOL | TKT | |||||||||||||
| GENE NAME | transketolase | |||||||||||||
| SYNONYMNS | TK, TKT1, HEL107 | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 68154 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Altertively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. We found combined effect of TKT SNP rs11130362 and FN3K SNP rs1056534 on DN progression (p<0.01). | 23492569 |
| Neuropathy | 1. associations of genetic variation in transketolase enzyme with neuropathic symptoms and reduced thermal sensation in recent-onset diabetes suggest a role of pathways metabolizing glycolytic intermediates in early diabetic neuropathy. | 27103086 |