| TLR3 |
| LOCUS ID | 7098 | ||||||||||
| GENE_SYMBOL | TLR3 | ||||||||||
| GENE NAME | toll like receptor 3 | ||||||||||
| SYNONYMNS | CD283 IIAE2 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 20696 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit dif |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.The anti-inflammatory impact of weight loss was concomitant with decreased TLR1, TLR3, and TLR8 in SAT. | 30476912 |