| TLR5 |
| LOCUS ID | 7100 | ||||||||||
| GENE_SYMBOL | TLR5 | ||||||||||
| GENE NAME | toll like receptor 5 | ||||||||||
| SYNONYMNS | SLE1 TIL3 SLEB1 MELIOS | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 20698 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Loss of TLR5 from DCs did not associate with development of inflammation-associated phenotypes or alterations in the composition of the microbiota but resulted in complete loss of flagellin-induced production of interleukin-22. | 25172014 |