| TNFRSF1A |
| LOCUS ID | 7132 | |||||||||||||
| GENE_SYMBOL | TNFRSF1A | |||||||||||||
| GENE NAME | TNF receptor superfa | |||||||||||||
| SYNONYMNS | FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55 | |||||||||||||
| CHROMOSOME | 12 | |||||||||||||
| HOMOLOGENE ID | 828 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor result |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Association of TNFR1 with markers of systemic inflammation and adipose stress indicates that TNFR1 may be a biomarker of these processes as components of the pathogenesis of diabetic kidney disease. | 29122448 |
| Insulin resistance and inflammation | 1.TNFR1 (TNFRSF1A) knock-out (TNFR1 KO) mice are protected from diet-induced obesity due to increased thermogenesis. | 19858212 |