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TNFRSF1B |
LOCUS ID | 7133 | ||||||||||
GENE_SYMBOL | TNFRSF1B | ||||||||||
GENE NAME | tumor necrosis facto | ||||||||||
SYNONYMNS | p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II | ||||||||||
CHROMOSOME | 1 | ||||||||||
HOMOLOGENE ID | 829 |
microRNAs | NA | NA |
GENE SUMMARY |
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor siglling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitition and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic sigls. Knockout stud |
OBSERVATIONS |
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Complication | Evidence | PMID |
Neuropathy | 1. Genetic variation in or near TNFRSF1B may predispose clinical neuropathy, reduced glycosylated hemoglobin, and increased HDL cholesterol in type 2 diabetes patients | 11315843 |