| TNFSF11 |
| LOCUS ID | 8600 | ||||||||||
| GENE_SYMBOL | TNFSF11 | ||||||||||
| GENE NAME | TNF superfamily memb | ||||||||||
| SYNONYMNS | ODF OPGL sOdf CD254 OPTB2 RANKL TNLG6B TRANCE hRANKL2 | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 2744 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Increased sRANKL and OPG levels were associated with prediabetic subjects. sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance. | 28146138 |