| TRAF1 |
| LOCUS ID | 7185 | ||||||||||
| GENE_SYMBOL | TRAF1 | ||||||||||
| GENE NAME | TNF receptor associa | ||||||||||
| SYNONYMNS | EBI6 MGC:10353 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 4138 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti- |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.TRAF1 expression was significantly upregulated in the livers of NAFLD patients and obese mice and in palmitate-treated hepatocytes. | 26860405 |