| TRAF2 |
| LOCUS ID | 7186 | ||||||||||
| GENE_SYMBOL | TRAF2 | ||||||||||
| GENE NAME | TNF receptor associa | ||||||||||
| SYNONYMNS | TRAP TRAP3 RNF117 MGC:45012 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 22520 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis pr |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Hepatocyte-specific TRAF2 knockout (HKO) mice exhibited normal body weight, blood glucose levels, and insulin sensitivity. Under HFD conditions, blood glucose levels were significantly lower (by >30%) in HKO than in control mice. | 22315325 |