| TRAF3 |
| LOCUS ID | 7187 | ||||||||||
| GENE_SYMBOL | TRAF3 | ||||||||||
| GENE NAME | TNF receptor associa | ||||||||||
| SYNONYMNS | CAP1 LAP1 CAP-1 CRAF1 IIAE5 CD40bp RNF118 | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 7981 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB act |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Myeloid cell-specific deletion of TRAF3 had the opposite effects on metabolic inflammation between obese and lean mice. | 25628422 |