| TREM2 |
| LOCUS ID | 54209 | ||||||||||
| GENE_SYMBOL | TREM2 | ||||||||||
| GENE NAME | triggering receptor | ||||||||||
| SYNONYMNS | PLOSL2 TREM-2 Trem2a Trem2b Trem2c | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 10352 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isof |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Trigger receptor expressed on myeloid cells 2 may function as a feedback mechanism to curb obesity-induced insulin resistance via regulating adipose tissue remodeling. | 31477129 |