| TRH |
| LOCUS ID | 7200 | ||||||||||
| GENE_SYMBOL | TRH | ||||||||||
| GENE NAME | thyrotropin releasin | ||||||||||
| SYNONYMNS | TRF, Pro-TRH | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 5163 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provid |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Our findings suggest that TRH has an acute effect on peripheral neuropathy in experimental streptozotocin diabetes in the rat. | 10414927 |