| Complication | Evidence | PMID |
| Nephropathy | 1. Finally, we demonstrate in murine tubular cells that TRB3 can inhibit secretion of IL-6. Thus, TRB3 reduces albuminuria and inflammatory gene expression in diabetic kidney disease by a mechanism that may involve inhibition of the mTORC2/AKT pathway and may prove to be a novel therapeutic target. . Our results indicate that smoking and the TRIB3 G-allele is associated with an increased risk of diabetic nephropathy, which supports the hypothesis that oxidative stress contributes to the development of diabetic nephropathy. | 24676635 |
| Cardiovascular | 1. Although preliminary, our finding suggests a role of TRIB3 low-frequency variants on CAD among Italian patients with T2D. | 26253791 |
| Insulin resistance and inflammation | 1.In streptozotocin diabetic mice, TRIB3 MOE (TRIB3 overexpressing) exacerbated, whereas MKO (TRIB3 knockout) prevented, glucose-induced insulin resistance and impaired glucose oxidation and defects in insulin signal transduction compared with wild-type (WT) mice, indicating that glucose-induced insulin resistance was dependent on TRIB3. | 27207527 |
