| TRIM8 |
| LOCUS ID | 81603 | ||||||||||
| GENE_SYMBOL | TRIM8 | ||||||||||
| GENE NAME | tripartite motif con | ||||||||||
| SYNONYMNS | GERP RNF27 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 12795 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Using gain-of-function and loss-of-function approaches, we observed dramatic exacerbation of insulin resistance, hepatic steatosis, inflammation, and fibrosis by hepatocyte-specific TRIM8 overexpression, whereas deletion or down-regulation of TRIM8 in hepatocytes led to a completely opposite phenotype. | 27981609 |