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TRIM8 |
LOCUS ID | 81603 | ||||||||||
GENE_SYMBOL | TRIM8 | ||||||||||
GENE NAME | tripartite motif con | ||||||||||
SYNONYMNS | GERP RNF27 | ||||||||||
CHROMOSOME | 10 | ||||||||||
HOMOLOGENE ID | 12795 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Insulin resistance and inflammation | 1.Using gain-of-function and loss-of-function approaches, we observed dramatic exacerbation of insulin resistance, hepatic steatosis, inflammation, and fibrosis by hepatocyte-specific TRIM8 overexpression, whereas deletion or down-regulation of TRIM8 in hepatocytes led to a completely opposite phenotype. | 27981609 |