| TRPM2 |
| LOCUS ID | 7226 | ||||||||||
| GENE_SYMBOL | TRPM2 | ||||||||||
| GENE NAME | transient receptor p | ||||||||||
| SYNONYMNS | KNP3 EREG1 TRPC7 LTRPC2 NUDT9H LTrpC-2 NUDT9L1 | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 20709 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. TRPM2-KO mice were more insulin sensitive partly because of increased glucose metabolism in peripheral organs. After 4 mo of high-fat feeding, TRPM2-KO mice were resistant to diet-induced obesity, and this was associated with increased energy expenditure and elevated expressions of PGC-1?, PGC-1?, PPAR?, ERR?, TFAM, and MCAD in white adipose tissue. | 22275755 |