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TRPV1 |
LOCUS ID | 7442 | ||||||||||
GENE_SYMBOL | TRPV1 | ||||||||||
GENE NAME | transient receptor p | ||||||||||
SYNONYMNS | VR1 | ||||||||||
CHROMOSOME | 17 | ||||||||||
HOMOLOGENE ID | 12920 |
microRNAs | NA | NA |
GENE SUMMARY |
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Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions |
OBSERVATIONS |
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Complication | Evidence | PMID |
Neuropathy | 1. The accumulation of TRPV1 and TRPV3 in peripheral nerves after injury, in spared axons, matches our previously reported changes in avulsed dorsal root ganglion (DRG). Reduction of TRPV1 levels in nerve fibres in diabetic neuropathy skin may from the known decrease of nerve growth factor (NGF) levels. | 17521436 |