| TSC22D1 |
| LOCUS ID | 8848 | ||||||||||
| GENE_SYMBOL | TSC22D1 | ||||||||||
| GENE NAME | TSC22 domain family | ||||||||||
| SYNONYMNS | Ptg-2, TSC22, TGFB1I4 | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 7573 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type triuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Altertively spliced tr |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. These findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of the diabetic nephropathy. | 12757981 |