| TSPO |
| LOCUS ID | 706 | |||||||||||||
| GENE_SYMBOL | TSPO | |||||||||||||
| GENE NAME | translocator protein | |||||||||||||
| SYNONYMNS | DBI, IBP, MBR, PBR, PBS, BPBS, BZRP, PKBS, PTBR, mDRC, pk18 | |||||||||||||
| CHROMOSOME | 22 | |||||||||||||
| HOMOLOGENE ID | 574 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Altertively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the sam |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Data here reported show for the first time that a TSPO ligand, such as Ro5-4864, is effective in reducing the severity of diabetic neuropathy through a local increase of neuroactive steroid levels. | 19665520 |
| Insulin resistance and inflammation | 1.TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). | 30984779 |