| TXNIP |
| LOCUS ID | 10628 | ||||||||||||||||
| GENE_SYMBOL | TXNIP | ||||||||||||||||
| GENE NAME | thioredoxin interact | ||||||||||||||||
| SYNONYMNS | THIF, VDUP1, HHCPA78, EST01027 | ||||||||||||||||
| CHROMOSOME | 1 | ||||||||||||||||
| HOMOLOGENE ID | 38186 |
| microRNAs | miR-17 | 26858253 |
| GENE SUMMARY |
|---|
| This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protei |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. TXNIP is associated with activation of oxidative stress and tubulointerstitial fibrosis in diabetic nephropathy. | 24492284 |
| Retinopathy | 1. In the pathogenesis of diabetic retinopathy, the genes associated with important enzymes (e.g., mitochondrial superoxide dismutase, matrix metalloproteinase-9 and thioredoxin interacting protein) and transcriptional factors are epigenetically modified, the enzymes responsible for these epigenetic modifications are either activated or inhibited, and the levels of microRNAs are altered. | 26025281 |
| Atherosclerosis | 1. The present study showed that plasma levels of TXNIP may be a useful predictor of subclinical atherosclerosis in Type 2 diabetic patients. | 26026780 |