| UCP1 |
| LOCUS ID | 7350 | |||||||||||||
| GENE_SYMBOL | UCP1 | |||||||||||||
| GENE NAME | uncoupling protein 1 | |||||||||||||
| SYNONYMNS | UCP, SLC25A7 | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 22524 |
| microRNAs | miR-106b,miR-93 | 23954633 |
| GENE SUMMARY |
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| Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. This study suggests that the SNP rs1800592 in the UCP1 gene is associated with increased risk of PDR in the Chinese T2DM population | 25274455 |
| Insulin resistance and inflammation | 1.PM2.5 exposure resulted in a significant increase in expression of inflammatory genes and decreased UCP1 expression in brown adipose tissue and activated p38 and ERK pathways in the liver of the KKay mice. | 24886175 |