| UHRF1 |
| LOCUS ID | 29128 | ||||||||||
| GENE_SYMBOL | UHRF1 | ||||||||||
| GENE NAME | ubiquitin-like with | ||||||||||
| SYNONYMNS | Np95, hNP95, ICBP90, RNF106, hUHRF1, huNp95 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 7866 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific D sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent D damage checkpoint. It is regarded as a hub protein for the in |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The expressions of UHRF1 and DNMT1 were increased in DN patients. | 26049093 |