| UNC5B |
| LOCUS ID | 219699 | ||||||||||
| GENE_SYMBOL | UNC5B | ||||||||||
| GENE NAME | unc-5 netrin recepto | ||||||||||
| SYNONYMNS | UNC5H2, p53RDL1 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 32538 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two altertively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice. Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease. | 25896231 |