| USF1 |
| LOCUS ID | 7391 | ||||||||||
| GENE_SYMBOL | USF1 | ||||||||||
| GENE NAME | upstream transcripti | ||||||||||
| SYNONYMNS | UEF FCHL MLTF FCHL1 MLTFI HYPLIP1 bHLHb11 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 31426 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.We show that Usf1 deficiency not only increases HDL-C levels in vivo, consistent with elevated ABCA1 protein expression in hepatic cell lines, but also improves the functional capacity of HDL particles. | 30545366 |