| USP18 |
| LOCUS ID | 11274 | ||||||||||
| GENE_SYMBOL | USP18 | ||||||||||
| GENE NAME | ubiquitin specific p | ||||||||||
| SYNONYMNS | ISG43 UBP43 PTORCH2 | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 8047 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this ge |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.When challenged with HFD, hepatocyte-specific USP18 transgenic mice exhibited improved lipid metabolism and insulin sensitivity, whereas mice knocked out of USP18 expression showed adverse trends regarding hepatic steatosis and glucose metabolic disorders. | 28718215 |