| USP4 |
| LOCUS ID | 7375 | ||||||||||
| GENE_SYMBOL | USP4 | ||||||||||
| GENE NAME | ubiquitin specific p | ||||||||||
| SYNONYMNS | UNP Unph | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 20716 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Hepatocyte-specific USP4 depletion exacerbated hepatic steatosis, insulin resistance and inflammatory response in HFD-induced NAFLD mice. | 29573006 |