| VCAM1 |
| LOCUS ID | 7412 | |||||||||||||
| GENE_SYMBOL | VCAM1 | |||||||||||||
| GENE NAME | vascular cell adhesi | |||||||||||||
| SYNONYMNS | CD106, INCAM-100 | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 838 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three altertively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1.The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis , and rheumatoid arthritis . Certain melanoma cells can use VCAM-1 to adhere to the endothelium, and VCAM-1 may participate in monocyte recruitment toatherosclerotic sites. As a result, VCAM-1 is a potential drug target | 26042828 |
| Cardiovascular | 1. up-regulation of FAS, FN1, SERPINE1, TGFB1, and VCAM1 might be associated with an increased cardiovascular risk | 23337395 |