| Complication | Evidence | PMID |
| Nephropathy | 1. Comparison of DN group and healthy subjects identified statistically significant difference for the FokI polymorphism in VDR gene (P<10-4) and also for the BstBI polymorphism in PTH gene (P=0,023). | 22777106 |
| Cardiovascular | 1. An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described | 26724524 |
| Retinopathy | 1. VDR rs2228570 might be good candidate biomarker of DR in Han Chinese T2DM patients. | 25899017 |
| Tuberculosis | 1. Results showed that DM2 group has lower VDR and AMPs expression levels. When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries | 25016144 |
| Atherosclerosis | 1. The 'G' allele of the VDR gene SNP is associated with a significant risk for T2DM, Diabetic Neuropathy (DN) and Coronary Artery Disease (CAD). In addition, subjects with mutant GG genotype had lower levels of (25[OH]D) in both T2DM and micro-macrovascular complications than AA genotype. Thus, VDR (rs1544410) SNP was found to be associated with decreased serum (25[OH]D) levels in both micro-macrovascular complications of T2DM among South Indian Population. | 25016144 |
| Insulin resistance and inflammation | 1.Importantly, pharmacological inhibition of BRD9 promotes PBAF-VDR association to restore ? cell function and ameliorate hyperglycemia in murine T2D models. | 29738868 |
