| VIP |
| LOCUS ID | 7432 | ||||||||||
| GENE_SYMBOL | VIP | ||||||||||
| GENE NAME | vasoactive intestil | ||||||||||
| SYNONYMNS | PHM27 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 2539 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Altertive splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Vasoactive intestil polypeptide (VIP) level in cerebrospil fluid (CSF) from diabetic patients was significantly decreased as compared with that from the controls (12. 9 +/- 3. 1 pg/ml vs. 35.4 +/- 3. 3 pg/ml, p less than 0.01).Decreased VIP level in CSF may relate with diabetic neuropathy in particular sexual dysfunction. | 2022357 |