| VLDLR |
| LOCUS ID | 7436 | ||||||||||
| GENE_SYMBOL | VLDLR | ||||||||||
| GENE NAME | very low density lip | ||||||||||
| SYNONYMNS | CAMRQ1 CARMQ1 CHRMQ1 VLDL-R VLDLRCH | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 443 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provid |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Elevated VLDLR expression in ATMs promotes adipose tissue inflammation and glucose intolerance in obese mice. | 29057873 |