| WT1 |
| LOCUS ID | 7490 | ||||||||||
| GENE_SYMBOL | WT1 | ||||||||||
| GENE NAME | Wilms tumor 1 | ||||||||||
| SYNONYMNS | GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 11536 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich D-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the materl and paterl alleles in different tissues. Multiple transcr |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The predomint presence of WT1 protein in Urinary exosomes of diabetic patients and increase in its expression level with decline in renal function suggest that it could be useful as early non-invasive marker for diabetic nephropathy. | 23544132 |