| XBP1 |
| LOCUS ID | 7494 | |||||||||||||
| GENE_SYMBOL | XBP1 | |||||||||||||
| GENE NAME | X-box binding protei | |||||||||||||
| SYNONYMNS | XBP2, TREB5, XBP-1, TREB-5 | |||||||||||||
| CHROMOSOME | 22 | |||||||||||||
| HOMOLOGENE ID | 3722 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the D binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endop |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Expression of the transcription factor XBP1 and the ER chaperones HSPA5 and HYOU1 were increased, but the proapoptotic gene DDIT3 was unchanged. These findings were replicated in an independent cohort of patients with established DN by real-time reverse transcriptase-PCR. | 18776125 |
| Insulin resistance and inflammation | 1.knockdown of XBP1 by siRNA markedly mitigated the protective effects of preconditioning against inflammation. | 31630283 |