XIAP
LOCUS ID331
GENE_SYMBOLXIAP
GENE NAMEX-linked inhibitor o
SYNONYMNSAPI3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3, hIAP-3
CHROMOSOMEX
HOMOLOGENE ID901
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by medione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of t

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. XIAP gene delivery through the neurosurgical delivery of viral vectors may provide a means for neuroprotection in ALS and diabetic neuropathy.16823314