| ZBTB16 |
| LOCUS ID | 7704 | ||||||||||
| GENE_SYMBOL | ZBTB16 | ||||||||||
| GENE NAME | zinc finger and BTB | ||||||||||
| SYNONYMNS | PLZF ZNF145 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 21214 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been c |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. | 28948820 |