| ZNRF1 |
| LOCUS ID | 84937 | ||||||||||
| GENE_SYMBOL | ZNRF1 | ||||||||||
| GENE NAME | zinc and ring finger | ||||||||||
| SYNONYMNS | NIN283 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 41858 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in syptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. We determined that rs17684886 and rs599019 are associated with diabetic retinopathy and that rs6427247 and rs899036 are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes. | 25819896 |