A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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Gene 1 | Gene 2 | SNP_Id | Allele | Chromosome | Chromosome Position | Functional Class | P-Value | Odds Ratio | PMID |
---|---|---|---|---|---|---|---|---|---|
Gene 1 | Gene 2 | SNP_id | Allele | Chro | Chr_positio | Functional_class | P-value | Odds_ratio | PMID |
ABCC8 | 26246406 | ||||||||
ACE | -- | D | 17 | -- | -- | 0.05 | 1.9 | 16621107 | |
ACHE | rs7636 | A | 7 | 100892456 | cds-synon | 0.000005 | 1.85 | 21490949 | |
AGTR1 | rs5186 | C | 3 | 148742201 | utr-variant-3-prime | -- | -- | 23081748 | |
AKR1B1 | rs759853 | T | 0.01 | 27640118 | |||||
ATP5F1P6 | RNA5SP220 | rs642858 | A | 6 | 139952510 | 0.000002 | 1.35 | 21490949 | |
C6orf57 | rs1048886 | G | 6 | 70579486 | missense | 0.00000003 | 1.54 | 21490949 | |
CDKAL1 | rs10946398 | C/A | 6 | 20660803 | intron-variant | 0.0016 | 1.18 | 20424228 | |
CDKN2A | rs10811661 | T | 9 | 22134095 | -- | 0.000051 | 1.37 | 20424228 | |
CDKN2A | rs2383208 | T | 9 | 22132077 | -- | 0.000003 | 1.23 | 23209189 | |
CETP | rs1800775 | -629C>A | 16 | 56961324 | upstream-variant-2KB | 0.000007 | 0.46 | 21185205 | |
CNDP1 | 0.004 | 27834323 | |||||||
CYP2C8 | CYP2C8*2(r | TT | 10 | 95058349 | missense,nc-transcript-variant,reference | <0.0003 | 3.9 | 28686288 | |
CYP2C9 | CYP2C9*2(r | TT,T | 10 | 94942290 | missense,reference | <0.03 | 2.4 | 28686288 | |
CYP2C9 | CYP2C9*3(r | AC | 10 | 94981296 | missense,reference | <0.0006 | 2.3 | 28686288 | |
DCDC2C | rs11677370 | T | 2 | 3793830 | intron | 0.000003 | 1.35 | 21490949 | |
DOK5 | rs6068915 | C/T | 20 | 54610242 | intron-variant | 0.019 | 0.75 | 20187968 | |
DOK5 | rs6064099 | G/C | 20 | 54643425 | intron-variant | 0.0068 | 0.48 | 20187968 | |
DOK5 | rs873079 | G/A | 20 | 54643947 | intron-variant | 0.036 | 0.76 | 20187968 | |
FOXA2 | rs1055080 | G | 20 | 22581800 | utr-variant-3-prime | 0.011 | 0.59 | 18797817 | |
FOXO1 | rs2297627 | intronic | 0.00087 | 1.34 | 26337673 | ||||
FTO | rs8050136 | A | 16 | 53782363 | intron-variant | 0.000006 | 1.16 | 23209189 | |
GSTM1 | -- | -- | 1 | -- | -- | 0.001 | 2.925 | 21352813 | |
GSTT1 | -- | -- | 15 | -- | -- | 0.001 | 3.114 | 21352813 | |
HHEX | rs1111875 | G/A | 10 | 94462882 | -- | 5.60E-10 | 1.12 | 20424228 | |
HMGB1P1 | rs328506 | C | 20 | 57454548 | -- | 0.000002 | 1.11 | 23300278 | |
HNF1A | -- | Ala98Val | 12 | -- | -- | -- | -- | 15277395 | |
HNF4A | rs1884613 | -- | 20 | 44351775 | intron-variant | 0.0000094 | 1.35 | 21814221 | |
HNF4A | rs2144908 | -- | 20 | 44357077 | intron-variant | 0.000006 | 1.37 | 21814221 | |
HP | 0.002 | 27190085 | |||||||
HSD11B1 | rs12086634 | T>G | 1 | 209706914 | intron-variant | 0.0001 | 23869418 | ||
IGF2BP2 | rs1470579 | C | 3 | 185811292 | intron-variant | 0.000005 | 1.19 | 23300278 | |
IGF2BP2 | rs4402960 | T/G | 3 | 185793899 | intron-variant | 0.000051 | 1.2 | 20424228 | |
INS | 27563254 | ||||||||
ITLN1 | rs1333062 | -- | 1 | 160876494 | intron-variant | 0.00018 | 1.19 | 22277902 | |
KCNJ11 | rs5219 | T/C | 11 | 17388025 | Intron-variant,missense,reference,stop-gained | 6.70E-11 | 1.39 | 20424228 | |
LEP | - | 26151423 | |||||||
MAP3K1 | rs10461617 | A | 5 | 56808481 | -- | 0.000004 | 1.17 | 23209189 | |
NEUROD1 | -- | Ala45Thr | 2 | -- | -- | -- | -- | 15277395 | |
NEUROG3 | rs3812704 | -- | 10 | 71334622 | upstream-variant-2KB | 0.00049 | 1.68 | 21814221 | |
NEUROG3 | -- | Ser199Phe | 10 | -- | -- | -- | -- | 15277395 | |
NXN | rs623323 | T | 17 | 796780 | -- | 0.000004 | 1.28 | 23300278 | |
PAPL | rs472265 | G | 19 | 39090097 | intron | 0.000009 | 1.39 | 21490949 | |
PLA2G4A | -- | C>A | 1 | -- | -- | -- | -- | 12765847 | |
PLS1 | rs3773506 | C | 3 | 142712158 | UTR-3 | 0.000009 | 1.81 | 21490949 | |
PON1 | -- | L55M | 7 | -- | -- | -- | -- | 22333293 | |
PPAI | rs6850 | A>G | 26702934 | ||||||
PPARG | rs1801282 | C/G | 3 | 12351626 | Intron-variant,missense,reference | 0.000016 | 1.37 | 20424228 | |
PPARGC1A | -- | Gly482Ser | 4 | -- | -- | -- | 1.66 | 21294239 | |
PPARGC1A | -- | Thr394Thr | 4 | -- | -- | -- | 1.72 | 21294239 | |
RHOU | rs6426514 | A | 1 | 228744368 | ncRNA | 0.000002 | 1.51 | 23300278 | |
SGCD | rs17053082 | T | 5 | 155967220 | -- | 0.0000004 | 1.49 | 23300278 | |
SGCG | rs9552911 | G | 13 | 23290518 | intron-variant | 0.00000002 | 1.49 | 23300278 | |
SLAMF1 | rs11265455 | -- | 16 | 85907666 | intron-variant | 0.000039 | 1.29 | 22277902 | |
SLC22A1 | rs622342 | 25492374 | |||||||
SLC22A11 | rs2078267 | 26902266 | |||||||
SLC30A8 | rs13266634 | C/T | 8 | 117172544 | missense,reference | 0.00000034 | 1.34 | 20424228 | |
SUMO4 | rs237025 | GG | 0.018 | 1.72 | 27055882 | ||||
TCERG1L | rs10741243 | G | 10 | 131149699 | intron | 0.000005 | 1.75 | 21490949 | |
TCF7L2 | rs7903146 | T | 10 | 114758349 | intron-variant | 4.60E-34 | 1.89 | 20424228 | |
TGFBR3 | rs11165354 | A | 1 | 91728765 | intron-variant | 0.000004 | 1.17 | 23209189 | |
THADA | rs7578597 | T | 2 | 43505684 | missense,nc-transcript-variant,reference | 0.03 | 1.5 | 22052079 | |
TMEM163 | rs6723108 | -- | 2 | 134722410 | 3.32E-29 | 1.31 | 23209189 | ||
TMEM163 | rs998451 | -- | 2 | 134671718 | intron-variant | 6.30E-12 | 1.56 | 23209189 | |
UCP2 | NA | G>A | 11 | -866 | promoter polymorphism | 0.001 | 1.48 | 30910560 | |
VDR | rs1544410 | C>A / C>G | 12 | 47846052?(G | VDR : Intron Variant | NA | NA | 29738868 | |
WFS1 | rs10010131 | G | 4 | 6291188 | intron-variant | -- | -- | 22513821 | |
WISP1 | rs4527850 | T | 8 | 133184606 | -- | 0.000002 | 1.23 | 23300278 | |
XRCC1 | 399Gln | 0.02 | 1.52 | 24621175 |