A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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Gene 1 | Gene 2 | SNP_Id | Allele | Chromosome | Chromosome Position | Functional Class | P-Value | Odds Ratio | PMID |
---|---|---|---|---|---|---|---|---|---|
ABCC8 | rs1799854 | T>T | 11 | 17448704 | intron-variant | -- | -- | 16873704 | |
AKR1B1 | -- | C-106T | 7 | -- | -- | 0.031 | 4.7 | 14582038 | |
ALOX5AP | rs3803278 | 8733T->C | 13 | 30744264 | intron-variant | 0.0036 | 0.73 | 19288030 | |
ANGPTL8 | rs2278426 | T/T,C/T | 19 | 11239812 | intron-variant,missense,reference | 0.0138 | 1.478 | 29397342 | |
ANK1 | rs515071 | C>T | 8 | 41519462 | intron-variant upstream-variant-2KB | 1.37E-08 | 1.18 | 22456796 | |
AP3S2 | rs2028299 | C | 15 | 90374257 | nc-transcript-variant utr-variant-3-prime | -- | 23029454 | ||
BTN2A1 | rs6929846 | C>T | 6 | 26458265 | utr-variant-5-prime | 0.0006 | 1.25 | 21672009 | |
C2CD4A | C2CD4B | rs7172432 | A | 15 | 62104190 | -- | 0.000001 | 1.11 | 23945395 |
CCR5 | -- | 52029A>G | 3 | -- | -- | 0.03 | 2.41 | 16442182 | |
CDKAL1 | rs7756992 | G | 6 | 20679709 | intron-variant | -- | -- | 19033397 | |
CDKAL1 | rs7754840 | C | 6 | 20661250 | intron-variant | -- | -- | 19033397 | |
CDKAL1 | rs4712523 | G | 6 | 20657333 | intron | 7.00E-20 | 1.27 | 19401414 | |
CDKAL1 | rs4712524 | G | 6 | 20657634 | intron | 3.00E-10 | 1.22 | 18711366 | |
CDKN2A | CDKN2B | rs2383208 | A | 9 | 22132077 | 2.00E-29 | 1.34 | 19401414 | |
CDKN2A | CDKN2B | rs10811661 | T | 9 | 22134094 | -- | -- | -- | 19033397 |
CLOCK | rs1801260 | C | 1.5 | 26374515 | |||||
CRTC2 | rs26759805 | 6909C>T | 1 | -- | -- | 0.016 | 3.01 | 17950019 | |
CTBP1-AS2 | rs7656416 | C>T | 4 | 1260747 | intron-variant | 1.37E-08 | 1.15 | 22456796 | |
DUSP9 | rs5945329 | T/G | 23 | 152910573 | intron-variant | 2.21E-08 | 1.39 | 23029454 | |
DUSP9 | rs5945326 | A | 23 | 153634467 | intron-variant | 2.00E-12 | 23945395 | ||
EPHX2 | -- | G860A | 8 | -- | -- | -- | -- | 15845398 | |
EVC | rs6414624 | 4 | 5741785 | missense,nc-transcript-variant,reference,upstream-variant-2KB | 29273463 | ||||
FABP2 | rs1799883 | Ala54Thr | 4 | 119320747 | missense,reference | 0.0482 | 1.23 | 19288030 | |
FADS1 | rs174550 | -- | 11 | 61571478 | intron-variant | 0.0071 | 1.12 | 22992776 | |
FTO | rs1558902 | 27820839 | |||||||
GPSM1 | rs11787792 | A | 9 | 136357696 | Intron-variant,missense,reference | 1.74E-10 | 1.15 | 23945395 | |
GYS1 | rs5447 | M416V | 19 | -- | -- | -- | -- | 9267990 | |
HHEX | rs7923837 | G | 10 | 94481917 | -- | -- | -- | 19033397 | |
HHEX | rs1111875 | C | 10 | 92703125 | 0.00000002 | 1.14 | 23945395 | ||
HHEX | rs1111875 | C | 10 | 92703125 | 7.00E-12 | 1.21 | 19401414 | ||
HNF1B | rs4430796 | G | 17 | 37738049 | intron-variant | 0.000004 | 1.11 | 23945395 | |
HNF2B | rs1016991 | T>T | 17 | 36058153 | intron-variant | -- | -- | 16873704 | |
HNF2B | rs2668 | A>A | 11 | 16996466 | intron-variant | -- | -- | 16873704 | |
HNF4A | rs745975 | T>T | 20 | 43034693 | intron-variant | -- | -- | 16873704 | |
IGF1 | 27060213 | ||||||||
IGF2BP2 | rs1470579 | C | 3 | 185529080 | intron-variant | -- | -- | 19033397 | |
IGF2BP2 | rs6769511 | C | 3 | 185812502 | intron | 0.000000001 | 1.23 | 18711366 | |
IGF2BP2 | rs4402960 | T | 3 | 185511687 | intron-variant | -- | -- | 19033397 | |
IGF2BP2 | rs4402960 | T | 3 | 185793899 | intron | 0.000001 | 1.14 | 19401414 | |
INS | 27316668 | ||||||||
IRAK1 | rs1059703 | Ser532Leu | X | 154013378 | Intron-variant,missense,reference | 0.0066 | 0.73 | 19288030 | |
IRS1 | rs2943641 | C | 2 | 227093745 | -- | 0.0034 | 1.15 | 22046406 | |
JAZF1 | rs864745 | T>C | 7 | 28180556 | intron-variant | 0.0098 | 1.148 | 19455301 | |
KCNJ11 | rs5219 | T | 11 | 17409572 | Intron-variant,missense,reference | -- | -- | 19033397 | |
KCNQ1 | rs2237892 | C | 11 | 2818521 | Intron-variant,nc-transcript-variant\ | 4.00E-29 | 1.3 | 23945395 | |
KCNQ1 | rs231362 | C | 11 | 2691471 | Intron-variant,nc-transcript-variant | 0.009 | 1.12 | 22046406 | |
KCNQ1 | rs2237892 | C | 11 | 2818521 | intron | 1.00E-26 | 1.33 | 19401414 | |
KCNQ1 | rs2237897 | C | 11 | 2837316 | intron | 1.00E-16 | 1.33 | 18711366 | |
KLF14 | rs972283 | G | 7 | 130466854 | -- | 0.017 | 1.07 | 22046406 | |
LEP | rs791595 | A | 7 | 128222749 | Intron-variant,missense,reference | 2.55E-13 | 1.17 | 23945395 | |
LMNA | rs4641 | 1908C/T | 1 | 156137743 | intron-variant | 0.0611 | 7.03 | 16117820 | |
MAEA | rs6815464 | G | 4 | 1316113 | intron-variant | 0.0000002 | 1.12 | 23945395 | |
MAEA | rs7656416 | -- | 4 | 1260747 | intron-variant | 0.00000001 | 1.15 | 22456796 | |
MPHOSPH9 | rs4275659 | 0.012 | 1.127 | 27115357 | |||||
MTNR1B | rs10930963 | G | 2 | 182135924 | -- | 0.033 | 1.06 | 22046406 | |
NKX2-2 | rs3746741 | A/C | 20 | 21491398 | downstream-variant-500B | -- | -- | 16873704 | |
NKX6-1 | rs1017560 | A/C | 4 | 85434987 | -- | -- | -- | 16873704 | |
PALM2 | rs1327796 | -- | 9 | 109764009 | intron-variant | 0.000003 | 1.13 | 22456796 | |
PAX4 | -- | Arg121Trp | 7 | -- | -- | -- | -- | 16423628 | |
PEPD | rs3786897 | A | 19 | 33402102 | intron-variant | 0.0407 | 1.09 | 24086726 | |
PRKAA2 | rs2051040 | GG | 1 | 57142755 | intron-variant | 0.002 | -- | 16567511 | |
PRKCB | -- | -105C>T | 16 | -- | -- | 0.015 | -- | 16567829 | |
PROX1 | rs340874 | -- | 1 | 214159256 | -- | 0.0078 | 1.12 | 22992776 | |
PSMD6 | rs831571 | C | 3 | 64062621 | -- | 0.0135 | 1.11 | 24086726 | |
PTEN | -- | C>G | 10 | -- | -- | -- | 14623110 | ||
RUFY1 | rs13831632 | T/G | 5q35 | <1.44 | 0.2 | 29113320 | |||
SLC16A13 | rs312457 | G | 17 | 7037074 | Intron-variant,missense,reference | 7.69E-13 | 1.2 | 23945395 | |
SLC30A8 | rs13266634 | C | 8 | 118184783 | missense,reference | -- | -- | 19033397 | |
SLC30A8 | rs13266634 | C | 8 | 117172544 | missense | 2.00E-14 | 1.22 | 19401414 | |
SOCS2 | rs12425869 | A/G | 12 | 93961353 | intron-variant | -- | -- | 16406727 | |
STK11 | rs741765 | -- | 19 | 1221545 | intron-variant | 0.017 | 1.33 | 17950019 | |
SYK | rs10993738 | -- | 9 | 90870958 | intron-variant | 0.000005 | 1.16 | 22456796 | |
TCF7L2 | rs12255372 | T | 10 | 114808902 | intron-variant | -- | 1.714 | 19033397 | |
TCF7L2 | rs7903146 | T | 10 | 112998590 | intron-variant | 2.00E-15 | 1.48 | 23945395 | |
TCF7L2 | rs7903146 | T | 10 | 112998590 | intron | 8.00E-12 | 1.54 | 19401414 | |
UBE2E2 | rs6780569 | G | 3 | 23156993 | -- | 0.0000004 | 1.17 | 23945395 | |
UCP1 | rs10011540 | -112A>C | 4 | 141493961 | -- | -- | -- | 16338218 | |
UTS2 | -- | S89N | 1 | -- | -- | 0.0018 | -- | 15476949 | |
ZPR1 | rs964184 | C | 27411854 |