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Diabetic Neuropathy

Go to Protective Genes for Neuropathy

Locus_Id Gene_Symbol Chromosome Homologene_Id Gene_Name Synonyms
6833ABCC81168048ATP binding cassette subfamily C member 8HI,SUR,HHF1,MRP8,PHHI,SUR1,ABC36,HRINS,TNDM2,SUR1delta2
1636ACE1737351angiotensin I converting enzymeDCP, ICH, ACE1, DCP1, CD
130399ACVR1C226724activin A receptor type 1CALK7, ACVRLK7
125ADH1B4133563alcohol dehydrogenase 1B (class I), beta polypeptideADH2, HEL-S-117
9370ADIPOQ33525adiponectin, C1Q and collagen domain containingACDC, ADPN, APM1, APM-1
133ADM11873adrenomedullinAM, PAMP
151ADRA2B2553adrenoceptor alpha 2BFAME2, ADRA2L1, ADRARL
177AGER6883advanced glycosylation end product-specific receptorRAGE
183AGT114angiotensinogen (serpin peptidase inhibitor, clade A, member 8)ANHU, SERPI8
231AKR1B17110647aldo-keto reductase family 1, member B1 (aldose reductase)AR, ADR, ALR2, ALDR1
213ALB4405albuminFDAH, ANALBA, PRO0883,
217ALDH21255480aldehyde dehydrogenase 2 family (mitochondrial)ALDM, ALDHI, ALDH-E2
8862APLNX8498apelinAPEL,XNPEP2
335APOA11147900apolipoprotein Aapo(a)
338APOB2328apolipoprotein BFLDB, LDLCQ4, apoB-48,
348APOE1930951apolipoprotein EAD2, LPG, APO-E, LDLCQ5
443ASPA1733aspartoacylaseASP, ACY2
468ATF4221266activating transcription factor 4CREB2, TXREB, CREB-2, TAXREB67
488ATP2A21280167ATPase, Ca++ transporting, cardiac muscle, slow twitch 2DD, DAR, ATP2B, SERCA2
623BDKRB114570bradykinin receptor B1B1R, BKR1, B1BKR, BKB1R
624BDKRB214519bradykinin receptor B2B2R, BK2, BK-2, BKR2, BR
627BDNF117245brain-derived neurotrophic factorANON2, BULN2
641BLM1547902 BLM RecQ like helicaseBS, RECQ2, RECQL2, RECQL3, MGRISCE1
708C1QBP1731023 complement C1q binding proteinp32, HABP1, gC1qR, GC1QBP, SF2p32, gC1Q-R, COXPD33, SF2AP32
8912CACNA1H1656913calcium channel, voltage-dependent, T type, alpha 1H subunitECA6, EIG6, Cav3.2, CAC
857CAV171330caveolin 1CGL3, PPH3, BSCL3, LCCN
885CCK3583cholecystokinin
6347CCL2172245chemokine (C-C motif) ligand 2HC11, MCAF, MCP1, MCP-1
1234CCR5337325chemokine (C-C motif) receptor 5 (gene/pseudogene)CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22,
9332CD16312128811CD163 moleculeM130, MM130
947CD3411343CD34 molecule
84735CNDP11857178carnosine dipeptidase 1 (metallopeptidase M20 family)CN1, CPGL2, HsT2308
1268CNR167273cannabinoid receptor 1 (brain)CB1, CNR, CB-R, CB1A, CB
1269CNR211389cannabinoid receptor 2CB2, CX5, CB-2
1270CNTF118288ciliary neurotrophic factorHCNTF
1392CRH8599corticotropin releasing hormoneCRF, CRH1
1398CRK1781850v-crk avian sarcoma virus CT10 oncogene homologp38, CRKII
1401CRP1128039C-reactive protein, pentraxin-relatedPTX1
1490CTGF61490Connective Tissue Growth FactorCCN2 NOV2 HCS24 IGFBP8
3627CXCL1041203chemokine (C-X-C motif) ligand 10C7, IFI10, INP10, IP-10
1649DDIT3123012DNA damage inducible transcript 3CHOP, CEBPZ, CHOP10, CH
8788DLK1142846 delta like non-canonical Notch ligand 1DLK, FA1, ZOG, pG2, DLK-1, PREF1, Delta1, Pref-1
1906EDN161476endothelin 1ET1, QME, PPET1, ARCND3
9844ELMO1756685engulfment and cell motility 1CED12, CED-12, ELMO-1
2022ENG992endoglinEND,HHT1,ORW1
5168ENPP284526ectonucleotide pyrophosphatase/phosphodiesterase 2ATX, NPP2, ATX-X, PDNP2
2056EPO7624erythropoietinEP, MVCD2
2064ERBB2173273erb-b2 receptor tyrosine kinase 2NEU, NGL, HER2, TKR1, CD
11082ESM155107endothelial cell specific molecule 1endocan
2157F8X49153coagulation factor VIII, procoagulant componentAHF, F8B, F8C, HEMA, FVI
2346FOLH111136782folate hydrolase (prostate-specific membrane antigen) 1PSM, FGCP, FOLH, GCP2, P
2353FOS143844FBJ murine osteosarcoma viral oncogene homologp55, AP-1, C-FOS
2539G6PDX37906glucose-6-phosphate dehydrogenaseG6PD1
2596GAP4331545growth associated protein 43B-50, PP46
2597GAPDH12107053glyceraldehyde-3-phosphate dehydrogenaseG3PD, GAPD, HEL-S-162eP
2629GBA168040 glucosylceramidase betaGCB, GBA1, GLUC
2645GCK755440glucokinaseGK, GLK, HK4, HHF3, HKIV, HXKP, LGLK, MODY2, FGQTL3
2668GDNF5433glial cell derived neurotrophic factorATF1, ATF2, HSCR3, HFB1
2670GFAP171554glial fibrillary acidic proteinALXDRD
2675GFRA28131781 GDNF family receptor alpha 2NTNRA, RETL2, TRNR2, GDNFRB, NRTNR-ALPHA
2678GGT12268450gamma-glutamyltransferase 1GGT, GTG, CD224, GGT, 1,
2695GIP173043gastric inhibitory polypeptide
2696GIPR1920081gastric inhibitory polypeptide receptorPGQTL2
2739GLO164880glyoxalase IGLYI, GLOD1, HEL-S-74
2740GLP1R61558glucagon like peptide 1 receptor
610HCN21931022hyperpolarization activated cyclic nucleotide gated potassium channel 2BCNG2, HAC-1, BCNG-2
3082HGF7503hepatocyte growth factor (hepapoietin A; scatter factor)SF, HGFB, HPTA, F-TCF, DFNB39
3162HMOX122heme oxygenase 1HSP32 HMOX1D bK286B10
3269HRH13668histamine receptor H1H1R, H1-R, HH1R, hisH1
3274HRH2540613histamine receptor H2H2R
3309HSPA593908heat shock protein family A (Hsp70) member 5BIP, MIF2, GRP78, HEL-S
10525HYOU1114658hypoxia up-regulated 1Grp170, HSP12A, ORP150
3458IFNG1255526interferon, gammaIFG, IFI
3479IGF112515insulin like growth factor 1MGF, IGFI, IGF-I
3481IGF211510insulin like growth factor 2GRDF, IGF-II, PP9974, C
3488IGFBP5256489insulin like growth factor binding protein 5IBP5
3586IL101478interleukin 10CSIF, TGIF, GVHDS, IL-1
3565IL45491interleukin 4BSF1, IL-4, BCGF1, BSF-
3569IL67502interleukin 6HGF, HSF, BSF2, IL-6, IFNB2
3630INS11173insulinIDDM, ILPR, IRDN, IDDM1, IDDM2, MODY10
3654IRAK1X37496interleukin 1 receptor associated kise 1IRAK, pelle
8660IRS2132778insulin receptor substrate 2IRS-2
55600ITLN11135852 intelectin 1HL1 LFR HL-1 INTL ITLN hIntL omentin
3767KCNJ1111441potassium channel, inwardly rectifying subfamily J, member 11BIR, HHF2, PHHI, IKATP,
3784KCNQ11185014potassium channel, voltage gated KQT-like subfamily Q, member 1LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KC8, KC9, Kv1.9, Kv7.1, KVLQT1
3952LEP7193leptinOB, OBS, LEPD
4023LPL8200lipoprotein lipaseLIPD, HDLCQ11
4035LRP1121744LDL receptor related protein 1APR, KPA, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R, IGFBP-3R, IGFBP3R1
5594MAPK12237670mitogen-activated protein kinase 1ERK, p38, p40, p41, ERK2
4153MBL210110436mannose-binding lectin (protein C) 2, solubleMBL, MBP, MBP1, MBPD, MB
4155MBP181788myelin basic protein
4282MIF2255655macrophage migration inhibitory factor (glycosylation-inhibiting factor)GIF, GLIF, MMIF
4311MME35275membrane metallo-endopeptidaseNEP, SFE, CD10, CALLA
4353MPO1755450myeloperoxidaseNA
4489MT1A16133258metallothionein 1AMT1, MTC, MT1S
4524MTHFR14349methylenetetrahydrofolate reductase (NAD(P)H)
4780NFE2L222412nuclear factor, erythroid 2 like 2NRF2, HEBP1
4803NGF11876nerve growth factor (beta polypeptide)NGFB, HSAN5, Beta-NGF
4804NGFR171877nerve growth factor receptorCD271, p75NTR, TNFRSF1
4842NOS11237327nitric oxide synthase 1 (neuronal)NOS, bNOS, nNOS, IHPS1,
4846NOS37504nitric oxide synthase 3eNOS, ECNOS
4852NPY7697neuropeptide YPYY4
4899NRF173674nuclear respiratory factor 1ALPHA-PAL
145957NRG41512921neuregulin 4HRG4
4908NTF3121896neurotrophin 3NT3, HDNF, NGF2, NT-3, N
22953P2RX21214251purinergic receptor P2X, ligand gated ion channel, 2P2X2, DFNA41
5024P2RX3111922purinergic receptor P2X, ligand gated ion channel, 3P2X3
5028P2RY131926purinergic receptor P2Y, G-protein coupled, 1P2Y1
5029P2RY2111927purinergic receptor P2Y, G-protein coupled, 2P2U, HP2U, P2U1, P2UR, P
57144PAK52022211p21 protein (Cdc42/Rac)-activated kinase 7PAK5
56924PAK61523200p21 protein (Cdc42/Rac)-activated kinase 6PAK5
8654PDE5A4842phosphodiesterase 5ACN5A, PDE5, CGB-PDE
5175PECAM11747925platelet/endothelial cell adhesion molecule 1CD31, PECA1, GPIIA&apo
5287PIK3C2B120582phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaC2-PI3K
5376PMP2217124423peripheral myelin protein 22DSS, HNPP, CMT1A, CMT1E
5428POLG152016DNA polymerase gamma, catalytic subunit PEO, MDP1, SCAE, MIRAS. POLG1, POLGA, SANDO, MTDPS4A, MTDPS4B
5443POMC2723proopiomelanocortinLPH, MSH, NPP, POC, ACTH, CLIP
5444PON177482paraoxonase 1ESA, PON, MVCD5
10891PPARGC1A47485peroxisome proliferator-activated receptor gamma, coactivator 1 alphaLEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1(alpha)
5538PPT1169192 palmitoyl-protein thioesterase 1 PPT, CLN1, INCL
5539PPY172039pancreatic polypeptidePNP
5579PRKCB1656424protein kinase C, betaPKCB, PRKCB1, PRKCB2, P
5592PRKG11055964protein kinase, cGMP-dependent, type IPKG, cGK, AAT8, cGK1, cG
8842PROM144390prominin 1RP41, AC133, CD133, MCD
5715PSMD91268058proteasome 26S subunit, non-ATPase 9p27, Rpn4
5728PTEN10265phosphatase and tensin homologBZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10
5743PTGS212106prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)COX2, COX-2, PHS-2, PGG
11021RAB351221361 RAB35, member RAS oncogene family RAY, H-ray, RAB1C
387RHOA368986ras homolog family member AARHA, ARH12, RHO12, RHO
27330RPS6KA6X22816ribosomal protein S6 kinase, 90kDa, polypeptide 6RSK4, PP90RSK4
6286S100P481743S100 calcium binding protein PMIG9
5176SERPINF1171965serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1OI6, OI12, PEDF, EPC-1,
23411SIRT11056556sirtuin 1SIR2L1
51548SIRT6196924sirtuin 6SIR2L6
6513SLC2A1168520solute carrier family 2 (facilitated glucose transporter), member 1CSE, PED, DYT9, GLUT, DYT17, DYT18, EIG12, GLUT1, HTLVR, GL
6515SLC2A31274302solute carrier family 2 (facilitated glucose transporter), member 3GLUT3
6517SLC2A41774381solute carrier family 2 (facilitated glucose transporter), member 4GLUT4
55532SLC30A101100946solute carrier family 30 member 10ZNT8, ZRC1, HMDPC, ZNT10, ZnT-10
6648SOD26530superoxide dismutase 2, mitochondrialIPOB, MNSOD, MVCD6
50964SOST1711542sclerostinCDD, VBCH, SOST1
6720SREBF1173079sterol regulatory element binding transcription factor 1SREBP1, bHLHd1, SREBP-
8867SYNJ12148252synaptojanin 1 synaptojanin 1
6855SYPX2391 synaptophysinMRX96, MRXSYP
7019TFAM1031139transcription factor A, mitochondrialTCF6, MTTF1, MTTFA, TCF
7054TH11307tyrosine hydroxylaseTYH, DYT14, DYT5b
7086TKT368154transketolaseTK,TKT1,SDDHD,HEL107,HEL-S-48
7099TLR49530toll-like receptor 4TOLL, CD284, TLR-4, ARM
7124TNF6496tumor necrosis factorDIF, TNFA, TNFSF2, TNLG1F, TNF-alpha
4982TNFRSF11B81912tumor necrosis factor receptor superfamily member 11bOPG, TR1, OCIF, PDB5
7133TNFRSF1B1496tumor necrosis factor receptor superfamily member 1Bp75, TBPII, TNFBR, TNFR
7189TRAF6113395TNF receptor associated factor 6RNF85, MGC:3310
7200TRH3829thyrotropin-releasing hormoneTRF, Pro-TRH
8989TRPA185163transient receptor potential cation channel, subfamily A, member 1FEPS, ANKTM1
7442TRPV1177189transient receptor potential cation channel, subfamily V, member 1VR1
201131TRPV31717040cation channel TRPV3
706TSPO2212920translocator proteinDBI, IBP, MBR, PBR, PBS,
7351UCP2112516uncoupling protein 2 (mitochondrial proton carrier)UCPH, BMIQ4, SLC25A8
23025UNC13A1911279unc-13 homolog A (C. elegans)Munc13-1
7421VDR1237297vitamin D receptorNR1I1 PPP1R163
7422VEGFA62534vascular endothelial growth factor AVPF, VEGF, MVCD1
7432VIP62516vasoactive intestinal peptidePHM27
7450VWF12466von Willebrand factorVWD, F8VWF
331XIAPX2539X-linked inhibitor of apoptosis, E3 ubiquitin protein ligaseAPI3, ILP1, MIHA, XLP2,
7515XRCC11931368X-ray repair complementing defective repair in Chinese hamster cells 1RCC